Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Antipyretic and Analgesic Effects of the Aqueous Extract of the Fruit Pulp of Hunteria umbellata K Schum (Apocynaceae)

Ighodaro Igbe¹ , Raymond I Ozolua¹, Steve O Okpo¹, Osahon Obasuyi²

¹Departments of Pharmacology & Toxicology; ²Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Benin City 300001, Nigeria.

For correspondence:- Ighodaro Igbe Email: igbero2002@yahoo.com Tel:+2348035023349

Received: 10 November 2008 Accepted: 16 May 2009 Published: 14 August 2009

Citation: Igbe I, Ozolua RI, Okpo SO, Obasuyi O. Antipyretic and Analgesic Effects of the Aqueous Extract of the Fruit Pulp of Hunteria umbellata K Schum (Apocynaceae). Trop J Pharm Res 2009; 8(4):331-336 doi: 10.4314/tjpr.v8i4.7

© 2009 The authors.
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Abstract

Purpose: The aqueous fruit pulp extract of Hunteria umbellata K. Schum is used traditionally for the treatment of various fevers. The purpose of this study was to evaluate the extract for antipyretic and analgesic activity, and determine its probable mechanism of action.

Methods: Pyrexia was induced in rabbits by intravenous injection of 10⁵CFU of E. coli/kg. Rectal temperature was monitored at 30, 60, and 90 min post-administration of 250 and 500 mg/kg of the extract. The analgesic effect of the extract was evaluated using acetic acid-induced mouse writhing test. The extract was tested for antimicrobial activity against Staphylococcus aureus, Klebsiella pnuemoniae, Escherichia coli, and Psuedomonas aeruginosa using agar diffusion method. Phytochemical screening of the plant extract was also carried out.

Results: Phytochemical screening revealed the presence of simple sugars, saponins, flavonoids, alkaloids and steroidal compounds. The extract (250, 500 mg/kg) and aspirin produced comparable antipyretic effects up to 60 min. The extract did not inhibit the growth of the microorganisms but significantly reduced the number of writhes in mice at 250 and 500 mg/kg with results comparable to ASA.

Conclusion: The extract possesses antipyretic and analgesic activities which validate its use in the treatment of pains and fevers.

Keywords: Hunteria umbellata; Anti-pyrexic; Analgesic; Antibacterial effect